Pre lab- Separation and Purity Techniques: Thin-Layer Chromatography and Melting

chemistry report and need the explanation and answer to help me learn.

I attached 3 pdf and one image. By looking at the questionnaire, I need to write down step by step procedure for this lab. So please look at the questionnaire to determine the procedure. for example, solvents that need to be dissolved, determining solubility of compounds, determine melting point, etc. basically look at the questions to create a step by step procedure

the rubric needs to be followed for this assignment. All criteria please. I want pass. For reagent table, I included an example to help, it needs to look similar to this so I need this pre lab assignment to include general info, apparatus, reaction, safety, procedure, comments, and reagent table

the image includes the 4 analogs that will be looked at in this lab

no plagiarism or AI, it will detect it.

Requirements: Whatever needed
Pre-Lab Rubric Pre-labs must be submitted to Blackboard by 8 AM on the day of your assigned lab. They are graded on a pass/do not pass basis according to the rubric below. All parts of the rubric need to be met at the pass level to pass the assignment. Component Do Not Pass Pass General Information Either the date or title are missing, or incomplete. The top of the page contains the date of the lab as well as the full title Apparatus/Reaction Apparatus is not fully drawn out or is missing labels. Reaction is missing or incorrect. Below the title, appears a drawing of the apparatus to be used. The drawing is labeled with names of the different parts of the apparatus, pieces of glassware, etc. If you are doing a reaction during lab, the reaction is drawn out clearly showing reactants and products. Reagent Table Reagent table is missing more than one chemical, or one or more of the things listed to the right. The reagent table contains all of the following: name of the chemical, molar mass, moles to be used, amount (g or mL) to be used, melting point and boiling point (if relevant), and density (if relevant). The reagent table should include all chemicals and solvents to be used in lab. Safety NFPA ratings are missing for more than one chemical, or especially harmful chemicals are lacking comments. NFPA rating is included for all reagents in the reagent table. Comments on any especially harmful chemicals are included (flammable, oxidizer, toxic, etc.). Procedure The procedure is missing or is written in an abbreviated way. The procedure is written out word for word in the lab notebook. Comments No space remains to the right of the procedure for comments. A space to the right of the procedure is left blank for comments.
CHM 2250 Winter 2023 ORGANIC CHEMISTRY LABORATORY I Separation and Purity Techniques: Thin-Layer Chromatography and Melting Point OBJECTIVES: 1) Investigate solubility of organo-metallic compounds 2) Advise a solvent system for proper separation of organo-metallic compounds on TLC plate 3) Determine the melting point of organo-metallic compounds Note: All background regarding TLC and melting point determination has been covered in previous activities. You are encouraged to refer to these documents for an overall review prior to completing this activity. Obtain some samples of ferrocene and its derivatives from the instructor and advise a solvent system for proper separation of these compounds on a TLC plate. Also, record melting points for these samples. Research Proposal Preliminary Data Questionnaire – Review MEMO Grading Rubric You are tasked to analyze ferrocene analogs and become familiar with working with a variety of these molecules. As organometallic complexes have distinct and diverse instrumental analyses resulting from the metal to organic ligand bonding, it is critical to note the difference and predict the instrumental signals for these complexes that might deviate from the original expected behavior of organic ligand in the absence of the metal. You are provided a set of analogs to analyze using organic techniques and instrumentation. An active anti-cancer ferrocene molecule will be assigned to your group and you are to predict the expected results using your information you find from studying the standard analogs. 1) From your measurements of the melting points of ferrocene, what did you note about purity? These samples have reported melting point ranges. 2) Was there a trend in the melting point with the change from the parent to the derivative compound? How does the structure of the analogs impact the melting point? Think about IMF/Supramolecular forces. 3) What solvent system worked for dissolving the solid samples prior to running a TLC plate? Why would you recommend that solvent system? 4) Did you establish a separation of the ferrocene compounds on TLC plate? What structural modifications does your assigned compound of interest have? 5) Based on the structure of our compound and the collected preliminary data, what do you expect the melting point and the polarity of your assigned compound of interest?
Compounds of interest – Your instructor will assign you a molecule of interest for your group
CHM 2250 Winter 2023 Organic Chemistry Laboratory I Handout 3 Reagent Table Sample An example is provided below for a reagent table including acetone as one of the chemicals for the experiment. (Hint: more than one chemical might be required, and you are required to list all ingredients as shown below unless stated otherwise by the instructor. You can type this reagent table and upload with your notebook pages if it is easier to submit. Compound Name IUPAC Name/Line Structure/ functional groups Hazardous labeling Safety Measurements Acetone IUPAC: Propan-2-one Line Diagram: Functional groups: Ketone classification with a carbonyl group on the 2nd carbon Physical properties: Boiling temperature: 56.0 °C Melting temperature: -97.5 °C Density: 0.783 g/mL Vapor Pressure: 30.0 kPa (@ 25 °C) Solubility: miscible in benzene, diethyl ether, methanol, ethanol, and chloroform Appearance: colorless liquid Odor: floural, cucumber Flash point: – 20 °C Viscosity: 0.295 m.Pa.s (@ 25 oC) Dipole moment: 2.91 D NFPA – Standard System for Identification for Hazards of Materials for Emergency Responses Red for flammability (3): Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions. Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). Blue for health (1): Exposure would cause irritation with only minor residual injury Yellow for instability (0): Normally stable, even under fire exposure conditions, and is not reactive with water White for special notices: none GHS Labels: Flammable and Harmful First aid measures: Eyes –immediately flood the eye with plenty of water for at least 15 minutes and get medical attention. Ingested – wash out mouth with water. Do not induce vomiting. Keep warm and at rest. Get medical attention urgently. Skin – remove contaminated clothing and wash skin thoroughly with water. If irritation persists get medical advice. Inhalation –Remove from exposure. Keep warm and at rest and get medical attention. 4.2. Most important symptoms and effects, both acute and delayed Causes redness and pain in the eyes. Inhalation can cause headache, dizziness or drowsiness. 4.3. Indication of any immediate medical attention and special treatment needed If not sure about any symptoms contact a doctor or emergency service. Fire Measures Extinguishing media Suitable extinguishing media – water spray, alcohol resistant foam, dry chemicals or carbon dioxide. Unsuitable extinguishing media – Do not use water jet. 5.2. Special hazards arising from the substance or mixture Combustion will generate oxides of carbon. Fire creates toxic gases/ vapours/fumes of carbon monoxide (CO) and Carbon dioxide (CO2 5.3. Advice for fire-fighters – Wear self-contained breathing apparatus. Personal equipment measures: Wear appropriate protective clothing (see Section 8), consider need for evacuation. Eliminate all source of ignition Spill and containment measures: Contain and absorb using inert material and transfer into suitable containers for recovery or disposal by a licensed waste contractor. Storage and handling Storage should be cool, well ventilated away from sources of ignition or heat. Prevent accumulation of static charge. Store in original packaging. Use in well ventilated area. Avoid inhaling vapor. Avoid contact with eyes, skin and clothing. Keep container tightly closed when not in use. Incompatible materials Strong oxidizing substances and strong acids

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